4-1-4-1 wide & 4-3-3 narrow (tested in serie a)
end of season:
serie a: 3rd place, 23-4-11 (73 pts), 71-46
italian cup: 1st place, 4-0-1 (pesciara won 5-4 in the semi final, but i advanced on away goals),9-5
eurocup: 1st place, 10-3-2 (started to use 4-1-4-1 from the last group game, cissé scored 14!), 37-13
in the 4-3-3 tactic, the DLC is actually an "attacking defender", supporting the midfield, and scoring 6 goals in the first season (materazzi scoring 6 and astori scoring another 3 when playing in this position, most of them from corners and freekicks).
started to use 4-1-4-1 regularly from the winter break, when i could sign labyad as a right winger, this was used by me mainly against the much stronger opponents, and the only thing you'll need is 2 fast wingers with good finishing and heading, because the crosses will usually reach the opposite winger (both lulic and labyad scoring above 10, and verratti 5 in this position)
conceding so many goals is quite unrealistic however, because if you check out the fixtures, you can see surprising home defeats, like the 0-4 from novara (they were the 1st team relegated from serie a), conceding 5 from pescara, 4 from bologna, chievo, lots of 95th minute goals conceded, etc ...
4-1-4-1 lazio jan_2012
4-3-3 lazio-narrow jul 2011
cissé's season (top scorer in euro cup, second best scorer in serie a):