My league campaign was 32-2-0 and we won the league by 37 points.
I have previously used it as a 5-2-3 but found that the extra striker wasn’t worth the loss of the DM.
I would recommend retraining players to fit into the system. Usually this would mean wingers and FBs into WBs and AMs into CMs or strikers.
I would also recommend that the WBs are on their natural side (i.e. WBL is left footed and WBR is right footed).
The WBs are going to get very tired in every game, I would recommend subbing and rotating very often.
With this formation the team averaged a chance every 35 minutes and conceded a chance every 164.