Long throw-ins, in my opinion, can be used just like a free-kick or a corner, if executed correctly. However, we won’t send our central defenders forward for this one, instead using just our midfielders and attackers. We want tactical solidity for this routine by keeping your defence intact. However, there are many possible routines which you can form and if you wish, you could throw your defenders forward.
We have the full-back set to “come short” in case that player is not taking the long-throw, to offer variety. The striker and the winger from the side of the throw will be at the near post, looking to latch on to the throw or flick it on/score. One of your midfielders lurks outside the area while the rest of your midfield/attack gets in to the box.
Having a player who possesses the PPM “possesses a long flat bullet throw” would be ideal for this sort of set-piece, and would be a very useful weapon!